Geminal Silicon/Zinc Reagent as an Equivalent of Difluoromethylene Bis-carbanion
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- 作者：Mikhail D. Kosobokov ; Vitalij V. Levin ; Artem A. Zemtsov ; Marina I. Struchkova ; Alexander A. Korlyukov ; Dmitry E. Arkhipov ; Alexander D. Dilman
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：March 7, 2014
- 年：2014
- 卷：16
- 期：5
- 页码：1438-1441
- 全文大小：296K
- 年卷期：v.16,no.5(March 7, 2014)
- ISSN：1523-7052
文摘
A new difluorinated reagent, [difluoro(trimethylsilyl)methyl]zinc bromide, bearing C鈥揨n and C鈥揝i bonds is described. The reagent is conveniently prepared by cobalt-catalyzed halogen/zinc exchange. It can be coupled with two different C-electrophiles in a stepwise manner (with allylic halides for C鈥揨n bond and aldehydes for C鈥揝i bond) affording products containing a difluoromethylene fragment.