Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion
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- 作者：Vitalij V. Levin ; Alexey L. Trifonov ; Artem A. Zemtsov ; Marina I. Struchkova ; Dmitry E. Arkhipov ; Alexander D. Dilman
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：December 5, 2014
- 年：2014
- 卷：16
- 期：23
- 页码：6256-6259
- 全文大小：343K
- ISSN：1523-7052
文摘
A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and azomethines is described. The reaction is performed using the readily available and air-stable reagent difluoromethylene phosphabetaine. The process involves interaction of an electrophilic substrate with in situ generated difluorinated phosphonium ylide followed by hydrolysis of the carbon鈥損hosphorus bond under mild conditions.