Development of a Small-Scale Automated Solubility Measurement Apparatus
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- 作者：Yongjin Yi ; Dimitri Hatziavramidis ; Allan S. Myerson ; Michael Waldo ; Vladimir G. Beylin ; and Jason Mustakis
- 刊名：Industrial & Engineering Chemistry Research
- 出版年：2005
- 出版时间：July 20, 2005
- 年：2005
- 卷：44
- 期：15
- 页码：5427 - 5433
- 全文大小：193K
- 年卷期：v.44,no.15(July 20, 2005)
- ISSN：1520-5045
文摘
A semiautomated device for solubility measurements in solution volumes as low as 1 mL wasdeveloped for pharmaceutical applications. The device operates nonisothermally, and can measuremultiple samples simultaneously. Solubilities of model compounds such as paracetamol, mannitol,adipic acid, and glycine were measured and showed a maximum deviation of 5 wt % comparedto literature data. Extrapolation of solubility data in the form of activity coefficients was foundin good agreement with the literature value over a wide range of temperatures for paracetamolin 2-propanol and adipic acid in ethanol, while some deviation was observed for mannitol inwater. The use of the solubility-measuring device to perform solvent screening on multiplesolvents for early-stage pharmaceutical compounds was also examined. Results indicate thatthe slope of the solubility curve with temperature can be estimated with limited data for multiplesolvents.