Induced Axial Chirality in the Biphenyl Core of the C-Tetrasubstituted <img src="http://pubs.acs.org/images/gifchars/alph
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- 作者：Jean-Paul Mazaleyrat ; Karen Wright ; Anne Gaucher ; Nathalie Toulemonde ; Michel Wakselman ; Simona Oancea ; Cristina Peggion ; Fernando Formaggio ; Vladimir Setni<img src="http ; //pubs.acs.org/images/entitie
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：October 13, 2004
- 年：2004
- 卷：126
- 期：40
- 页码：12874 - 12879
- 全文大小：104K
- 年卷期：v.126,no.40(October 13, 2004)
- ISSN：1520-5126
文摘
In the dipeptides Boc-Bip-L-Val-OMe and Boc-Bip-D-Val-OMe, an induced axial chirality in thebiphenyl core of the Bip residue, a conformationally labile, proatropoisomeric C<IMG SRC="/images/gifchars/alpha.gif" BORDER=0>
-disubstituted glycine,was observed by electronic CD and 1H NMR. Chiral induction is significantly higher when the Val residueis located at the C-terminal position of Bip. An outstanding phenomenon of propagation of chirality wasdemonstrated to occur in the related 310-helical -(Bip)n-L-Val (n = 2-6) oligopeptides by CD and vibrationalCD techniques.
-disubstituted glycine,was observed by electronic CD and 1H NMR. Chiral induction is significantly higher when the Val residueis located at the C-terminal position of Bip. An outstanding phenomenon of propagation of chirality wasdemonstrated to occur in the related 310-helical -(Bip)n-L-Val (n = 2-6) oligopeptides by CD and vibrationalCD techniques.