Stereochemically General Approach to Adjacent Bis(tetrahydrofuran) Cores of Annonaceous Acetogenins

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• 作者：Laura M. Wysocki ; Matthew W. Dodge ; Eric A. Voight ; Steven D. Burke
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：November 23, 2006
• 年：2006
• 卷：8
• 期：24
• 页码：5637 - 5640
• 全文大小：97K
• 年卷期：v.8,no.24(November 23, 2006)
• ISSN：1523-7052

文摘

ABLE>als/orlef7/8/i24/figures/ol062390ln00001.gif" ALIGN="left" HSPACE=5>A series of six 2,5-disubstituted adjacent bis(tetrahydrofuran) stereoisomers with trans/erythro/cis, trans/threo/trans, or cis/threo/cis relativestereochemistry have been synthesized from known dihydroxycyclooctenes via ring opening/cross metathesis and Pd(0)-mediated asymmetricdouble cycloetherification. The stereochemistry of four of these isomers has been found in the biologically active annonaceous acetogeninnatural products.