Facile Synthesis of β-Cyclodextrin-Dextran Polymers by “Click” Chemistry
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- 作者：Thorbjø ; rn Terndrup Nielsen ; Vronique Wintgens ; Catherine Amiel ; Reinhard Wimmer ; Kim Lambertsen Larsen
- 刊名：Biomacromolecules
- 出版年：2010
- 出版时间：July 12, 2010
- 年：2010
- 卷：11
- 期：7
- 页码：1710-1715
- 全文大小：249K
- 年卷期：v.11,no.7(July 12, 2010)
- ISSN：1526-4602
文摘
Three series of novel water-soluble β-cyclodextrin-dextran polymers have been prepared by “click” chemistry. The polymers were synthesized from alkyne-modified dextrans (AMDs) onto which mono-6-O-deoxy-monoazido-βCD (N3βCD) was grafted by a copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC). The polymers have been characterized by NMR spectroscopy and size exclusion chromatography (SEC). The binding properties have been characterized by isothermal titration calorimetry (ITC) and show excellent accessibility of the βCDs.