Preclinical Evaluation of Rapeseed, Raspberry, and Pine Bark Phenolics for Health Related Effects

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• 作者：Satu Vuorela ; Kari Kreander ; Maarit Karonen ; Riina Nieminen ; Mari H&auml ; m&auml ; l&auml ; inen ; Anna Galkin ; Leena Laitinen ; Juha-Pekka Salminen ; Eeva Moilanen ; Kalevi Pihlaja ; Heikki Vuorela ; Pia Vuorel
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：July 27, 2005
• 年：2005
• 卷：53
• 期：15
• 页码：5922 - 5931
• 全文大小：259K
• 年卷期：v.53,no.15(July 27, 2005)
• ISSN：1520-5118

文摘

Rapeseed, raspberry, and pine bark are promising bioactive sources of plant phenolics selected fromamong ca. 100 previously screened plant materials for in vitro preclinical evaluation of health relatedeffects. Phenolic extracts and isolated fractions of the selected materials were investigated forantioxidant, antimicrobial, antiinflammatory, and antimutagenic properties as well as for cellpermeability. It was shown that rapeseed and pine bark phenolics and raspberry anthocyanins weregood or excellent antioxidants toward oxidation of phosphatidylcholine membrane (liposomes),rapeseed oil (crude) phenolics were effective radical scavengers (DPPH test), and both raspberryand pine bark phenolics inhibited LDL oxidation. Rapeseed oil phenolics, principally vinylsyringol,raspberry anthocyanins, and pinoresinol and matairesinol, the principal components of pine barkphenolic isolate, were effective against formation of the proinflammatory mediator, prostaglandin E₂.Raspberry ellagitannins inhibited the growth of Proteus mirabilis and Klebsiella oxytoca. Pine barkand rapeseed had minor effects on the permeability of model drugs in Caco-2 experiments. None ofthe tested extracts were mutagenic nor toxic to Caco-2 cells or macrophages. Thus, phenolic isolatesfrom rapeseed, raspberry, and pine bark and are safe and bioactive for possible food applicationsincluding functional foods intended for health benefit.Keywords: Bioactivity tests; raspberry; pine bark and rapeseed phenolics