Building Biologics by Chemical Synthesis: Practical Preparation of Di- and Triantennary N-Linked Glycoconjugates

详细信息    查看全文

• 作者：Maciej A. Walczak ; Joji Hayashida ; Samuel J. Danishefsky
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：March 27, 2013
• 年：2013
• 卷：135
• 期：12
• 页码：4700-4703
• 全文大小：378K
• 年卷期：v.135,no.12(March 27, 2013)
• ISSN：1520-5126

文摘

A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described.