Houttuynoids A鈥揈, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata

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• 作者：Shao-Dan Chen ; Hao Gao ; Qin-Chang Zhu ; Ya-Qi Wang ; Ting Li ; Zhen-Qiang Mu ; Hong-Ling Wu ; Tao Peng ; Xin-Sheng Yao
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：14
• 期：7
• 页码：1772-1775
• 全文大小：211K
• 年卷期：v.14,no.7(April 6, 2012)
• ISSN：1523-7052

文摘

Houttuynoids A鈥揈 (1鈥?b>5), a new type of flavonoid with houttuynin tethered to hyperoside, and their presumed biosynthetic precursor hyperoside (6) were isolated from the whole plant of Houttuynia cordata. Their structures were elucidated by analysis of 1D and 2D NMR. A hypothetical biogenetic pathway for houttuynoids A鈥揈 was proposed. Compounds 1鈥?b>5 exhibited potent anti-HSV (herpes simplex viruses) activity.