Cembranoids from the Gum Resin of Boswellia carterii as Potential Antiulcerative Colitis Agents

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• 作者：Jin Ren ; Yan-Gai Wang ; Ai-Guo Wang ; Lian-Qiu Wu ; Hai-Jing Zhang ; Wen-Jie Wang ; Ya-Lun Su ; Hai-Lin Qin
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2322-2331
• 全文大小：500K
• ISSN：1520-6025

文摘

Eight new cembranoids, boscartins A鈥揌 (1, 2, and 4鈥?b>9), and the known incensole oxide were isolated from the gum resin of Boswellia carterii. The absolute configurations of 1, 2, 4, and incensole oxide were unequivocally resolved using single-crystal X-ray diffraction analysis with Cu K伪 radiation, and the absolute configuration of 5 was resolved via electronic circular dichroism data. The antiulcerative colitis activities of the compounds were evaluated in an in vitro x-box-binding protein 1 (XBP 1) transcriptional activity assay using dual luciferase reporter detection. At 10 渭M, compounds 1, 5, 6, and 7 significantly activated XBP 1 transcription with EC₅₀ values of 0.34, 1.14, 0.88, and 0.42 渭M, respectively, compared with the pGL3-basic vector control.