Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp3)鈥揌 Functionalization
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- 作者：Ben Niu ; Wannian Zhao ; Yingcai Ding ; Zhaogang Bian ; Charles U. Pittman ; Jr. ; Aihua Zhou ; Haibo Ge
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：July 17, 2015
- 年：2015
- 卷：80
- 期：14
- 页码：7251-7257
- 全文大小：435K
- ISSN：1520-6904
文摘
Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C(sp3)鈥揌 functionalization processes were developed, generating new ether-substituted derivatives not previously reported. These reactions proceeded well via radical mechanisms and provided the corresponding products in good yields.