Palladium-Catalyzed Oxidative Annulation of Acrylic Acid and Amide with Alkynes: A Practical Route to Synthesize 伪-Pyrones and Pyridones
详细信息 查看全文
- 作者：Yue Yu ; Liangbin Huang ; Wanqing Wu ; Huanfeng Jiang
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：April 18, 2014
- 年：2014
- 卷：16
- 期：8
- 页码：2146-2149
- 全文大小：324K
- 年卷期：v.16,no.8(April 18, 2014)
- ISSN：1523-7052
文摘
A range of internal alkynes smoothly underwent palladium-catalyzed oxidative annulations with acrylic acid and amide to afford 伪-pyrones and pyridones in good to excellent yields with high regioselectivity. The usage of O2 (1 atm) as a stoichiometric oxidant with H2O as the only byproduct under mild conditions makes this process more attractive and practical.