A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition

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• 作者：Wanxiang Zhao ; Zigang Li ; Jianwei Sun
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：March 27, 2013
• 年：2013
• 卷：135
• 期：12
• 页码：4680-4683
• 全文大小：359K
• 年卷期：v.135,no.12(March 27, 2013)
• ISSN：1520-5126

文摘

We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.