Surface Re-engineering of Pancreatic Islets with Recombinant azido-Thrombomodulin

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• 作者：Cherie L. Stabler ; Xue-Long Sun ; Wanxing Cui ; John T. Wilson ; Carolyn A. Haller ; Elliot L. Chaikof
• 刊名：Bioconjugate Chemistry
• 出版年：2007
• 出版时间：November 2007
• 年：2007
• 卷：18
• 期：6
• 页码：1713 - 1715
• 全文大小：632K
• 年卷期：v.18,no.6(November 2007)
• ISSN：1520-4812

文摘

Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses.