A General Thermolabile Protecting Group Strategy for Organocatalytic Metal鈭扥rganic Frameworks

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• 作者：David J. Lun ; Geoffrey I. N. Waterhouse ; Shane G. Telfer
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：April 20, 2011
• 年：2011
• 卷：133
• 期：15
• 页码：5806-5809
• 全文大小：758K
• 年卷期：v.133,no.15(April 20, 2011)
• ISSN：1520-5126

文摘

We present a general strategy for incorporating organocatalytic moieties into metal鈭抩rganic frameworks (MOFs). The organocatalytic units are protected by a thermolabile protecting group during MOF synthesis and then unveiled by a simple postsynthetic heating step. The strategy is exemplified using a thermolabile <i>terti>-butoxycarbonyl (Boc) protecting group for a proline moiety, the removal of which endows the resulting cubic zinc(II) IRMOF with catalytic activity for asymmetric aldol reactions. The bulky Boc groups also prevent framework interpenetration, producing open MOFs that can admit relatively large substrates.