Intermolecular Zirconium-Catalyzed Hydrophosphination of Alkenes and Dienes with Primary Phosphines

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• 作者：Michael B. Ghebreab ; Christine A. Bange ; Rory Waterman
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：July 2, 2014
• 年：2014
• 卷：136
• 期：26
• 页码：9240-9243
• 全文大小：223K
• ISSN：1520-5126

文摘

Catalytic hydrophosphination of terminal alkenes and dienes with primary phosphines (RPH₂; R = Cy, Ph) under mild conditions has been demonstrated using a zirconium complex, [魏⁵-N,N,N,N,C-(Me₃SiNCH₂CH₂)₂NCH₂CH₂NSiMe₂CH]Zr (1). Exclusively anti-Markovnikov functionalized products were observed, and the catalysis is selective for either the secondary or tertiary phosphine (i.e., double hydrophosphination) products, depending on reaction conditions. The utility of the secondary phosphine products as substrates for further elaboration was demonstrated with a platinum-catalyzed asymmetric alkylation reaction.