Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum

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• 作者：Haoxin Li ; St茅phanie Jean ; Duncan Webster ; Gilles A. Robichaud ; Larry A. Calhoun ; John A. Johnson ; Christopher A. Gray
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2837-2840
• 全文大小：272K
• ISSN：1520-6025

文摘

Two new dibenz[b,f]oxepins, empetroxepins A and B (1 and 2), and seven known compounds (3鈥?b>9) were isolated from an extract of the Canadian medicinal plant Empetrum nigrum that significantly inhibited the growth of Mycobacterium tuberculosis H37Ra. The structures of 1 and 2 were established through analysis of NMR and MS data. The antimycobacterial activity of the plant extract was attributed primarily to the presence of two chalcone derivatives (6 and 7) that exhibited selective antimycobacterial activity (IC₅₀ values of 23.8 and 32.8 渭M, respectively) in comparison to mammalian (HEK 293) cells (IC₅₀ values of 109 and 249 渭M, respectively).