Probing into the Supramolecular Driving Force of an Amphiphilic 尾-Cyclodextrin Dimer in Various Solvents: Host鈥揋uest Recognition or Hydrophilic鈥揌ydrophobic Interaction?

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• 作者：Yang Bai ; Xiao-dong Fan ; Hao Yao ; Zhen Yang ; Ting-ting Liu ; Hai-tao Zhang ; Wan-bin Zhang ; Wei Tian
• 刊名：Journal of Physical Chemistry B
• 出版年：2015
• 出版时间：September 3, 2015
• 年：2015
• 卷：119
• 期：35
• 页码：11893-11899
• 全文大小：464K
• ISSN：1520-5207

文摘

Tuning of the morphology and size of supramolecular self-assemblies is of theoretical and practical significance. To date, supramolecular driving forces in different solvents remain unclear. In this study, we first synthesized an amphiphilic 尾-cyclodextrin (尾-CD) dimer that consists of one hydrophobic ibuprofen (Ibu) and two hydrophilic 尾-CD moieties (i.e., Ibu-CD₂). Ibu-CD₂ possesses double supramolecular driving forces, namely, the host鈥揼uest recognition and hydrophilic鈥揾ydrophobic interaction. The host鈥揼uest interaction of Ibu-CD₂ induced the formation of branched supramolecular polymers (SPs) in pure water, whereas the hydrophilic鈥揾ydrophobic interaction generated spherical or irregular micelles in water/organic mixtures. The SP size increased with the increase in Ibu-CD₂ concentration in pure water. By contrast, the size of micelles decreased with the increase in volume ratio of water in mixtures.