Potent HGF/c-Met Axis Inhibitors from Eucalyptus globulus: the Coupling of Phloroglucinol and Sesquiterpenoid Is Essential for the Activity
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- 作者：Sheng-Ping Yang ; Xiao-Wei Zhang ; Jing Ai ; Li-She Gan ; Jin-Biao Xu ; Ying Wang ; Zu-Shang Su ; Lu Wang ; Jian Ding ; Mei-Yu Geng ; Jian-Min Yue
- 刊名：Journal of Medicinal Chemistry
- 出版年：2012
- 出版时间：September 27, 2012
- 年：2012
- 卷：55
- 期：18
- 页码：8183-8187
- 全文大小：285K
- 年卷期：v.55,no.18(September 27, 2012)
- ISSN：1520-4804
文摘
Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure鈥揳ctivity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity.