Phorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp.

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• 作者：Weihong Wang ; Yehee Lee ; Tae Gu Lee ; Bora Mun ; Awadut G. Giri ; Jihye Lee ; Hiyoung Kim ; Dongyup Hahn ; Inho Yang ; Jungwook Chin ; Hyukjae Choi ; Sang-Jip Nam ; Heonjoong Kang
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4486-4489
• 全文大小：253K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new 鈥減horane鈥?5) and 鈥渋sophorbasane鈥?6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC₅₀ values of 4.5 and 2.8 渭M, respectively.