Design and Synthesis of a Ratiometric Fluorescent Chemosensor for Cu(II) with a Fluorophore Hybridization Approach

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• 作者：Zhipeng Liu ; Changli Zhang ; Xiaoqing Wang ; Weijiang He ; Zijian Guo
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4378-4381
• 全文大小：263K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

A new ratiometric fluorescent sensor for Cu²⁺, WLN, has been developed via integrating a 1,8-naphthalimide fluorophore with 8-aminoquinoline. WLN exhibits a highly selective ratiometric response to Cu²⁺ over other transition metal ions in aqueous media. Moreover, its practical ratiometric imaging ability for intracellular Cu²⁺ has been confirmed in human breast adenocarcinoma cells (MCF-7 cells) using a confocal microscope.