Controllable in Situ Synthesis of Magnetite Coated Silica-Core Water-Dispersible Hybrid Nanomaterials

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• 作者：Haiou Qu ; Sheng Tong ; Kejing Song ; Hui Ma ; Gang Bao ; Seth Pincus ; Weilie Zhou ; Charles O鈥機onnor
• 刊名：Langmuir
• 出版年：2013
• 出版时间：August 20, 2013
• 年：2013
• 卷：29
• 期：33
• 页码：10573-10578
• 全文大小：372K
• 年卷期：v.29,no.33(August 20, 2013)
• ISSN：1520-5827

文摘

Magnetite nanoparticle coated silica (Fe₃O₄@SiO₂) hybrid nanomaterials hold an important position in the fields of cell imaging and drug delivery. Here we report a large scale synthetic procedure that allows attachment of magnetite nanoparticles onto a silica surface in situ. Many different silica nanomaterials such as St枚ber silica nanospheres, mesoporous silica nanoparticles, and hollow silica nanotubes have been coated with a high density layer of water-dispersible magnetite nanoparticles. The size and attachment efficiency of the magnetite nanoparticle can be well tuned by adjusting the precursor concentration and reflux time. The functionalization of Fe₃O₄@SiO₂ nanoparticles with dye molecules and biocompatible polymers impart optical imaging modality and good colloidal stability in either buffer solution or serum. The functionalized materials also exhibited strong potential as negative contrast agents in T₂ weighted magnetic resonance imaging.