Sensing of Bacterial Endotoxin in Aqueous Solution by Supramolecular Assembly of Pyrene Derivative

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• 作者：Lintao Zeng ; Jiasheng Wu ; Qing Dai ; Weimin Liu ; Pengfei Wang ; Chun-Sing Lee
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：September 17, 2010
• 年：2010
• 卷：12
• 期：18
• 页码：4014-4017
• 全文大小：202K
• 年卷期：v.12,no.18(September 17, 2010)
• ISSN：1523-7052

文摘

N,N-Dimethyl-N-(pyrenyl-1-methyl) dodecan-1-ammonium has been designed and applied as a fluorescent probe for sensing bacterial endotoxin. Upon assembly with bacterial endotoxin (lipopolysaccharide) in aqueous solution, the probe exhibits a ratiometric and sensitive fluorescence response with a low detection limit (100 nM). Moreover, the probe shows high selectivity for bacterial endotoxin over other related biological species.