Cyclic Heptapeptides, Cordyheptapeptides C鈥揈, from the Marine-Derived Fungus Acremonium persicinum SCSIO 115 and Their Cytotoxic Activities

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• 作者：Ziming Chen ; Yongxiang Song ; Yuchan Chen ; Hongbo Huang ; Weimin Zhang ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：June 22, 2012
• 年：2012
• 卷：75
• 期：6
• 页码：1215-1219
• 全文大小：282K
• 年卷期：v.75,no.6(June 22, 2012)
• ISSN：1520-6025

文摘

Three new cycloheptapeptides, cordyheptapeptides C鈥揈 (1鈥?b>3), were isolated from the fermentation extract of the marine-derived fungus Acremonium persicinum SCSIO 115. Their planar structures were elucidated on the basis of extensive MS, as well as 1D and 2D (COSY, HMQC, and HMBC) NMR spectroscopic data analyses. The absolute configurations of the amino acid residues were determined by single-crystal X-ray diffraction, Marfey鈥檚 method, and chiral-phase HPLC analysis. Compounds 1 and 3 displayed cytotoxicity against SF-268, MCF-7, and NCI-H460 tumor cell lines with IC₅₀ values ranging from 2.5 to 12.1 渭M.