Some Reaction Safety Aspects of Ruthenium-Catalyzed Allylic Oxidations of -5-Steroids in the Pilot Plant
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- 作者：Michael Harre ; Reinhard Haufe ; Klaus Nickisch ; Peter Weinig ; Hilmar Weinmann ; William A. Kinney ; and Xuehai Zhang
- 刊名：Organic Process Research & Development
- 出版年：1998
- 出版时间：March 1998
- 年：1998
- 卷：2
- 期：2
- 页码：100 - 104
- 全文大小：66K
- 年卷期：v.2,no.2(March 1998)
- ISSN：1520-586X
文摘
The ruthenium-catalyzed allylic oxidation of 
-5-steroidswithtert-butyl hydroperoxide to the correspondingunsaturatedketones was studied. During the scale-up to the pilot plantlevel,serious safety problems were detected, and the identifiedrunaway potential of this reaction was studied. Bymodifyingthe original oxidation procedure, it was possible toestablishthis reaction safely in the pilot plant at 17-kg scale.Furthermore, the procedure was applied successfully to severalothersteroids on the laboratory scale.
-5-steroidswithtert-butyl hydroperoxide to the correspondingunsaturatedketones was studied. During the scale-up to the pilot plantlevel,serious safety problems were detected, and the identifiedrunaway potential of this reaction was studied. Bymodifyingthe original oxidation procedure, it was possible toestablishthis reaction safely in the pilot plant at 17-kg scale.Furthermore, the procedure was applied successfully to severalothersteroids on the laboratory scale.