Production of Hydroxylated Polybrominated Diphenyl Ethers from Bromophenols by Bromoperoxidase-Catalyzed Dimerization
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- 作者：Kunde Lin ; Jay Gan ; Weiping Liu
- 刊名：Environmental Science & Technology
- 出版年：2014
- 出版时间：October 21, 2014
- 年：2014
- 卷：48
- 期：20
- 页码：11977-11983
- 全文大小：439K
- ISSN：1520-5851
文摘
Hydroxylated polybrominated diphenyl ethers (HO-PBDEs) are emerging endocrine-disrupting compounds that are widely present in the marine environment. The origin of HO-PBDEs is generally attributed to metabolism of PBDEs and natural production in the environment. However, it is unclear how HO-PBDEs are produced naturally. Here we report the formation of HO-PBDEs from simple bromophenols (BPs) [e.g., 2,4-dibromophenol (2,4-DBP) and 2,4,6-tribromophenol (2,4,6-TBP)] under the catalysis of bromoperoxidase (BPO) isolated from the common marine red alga Corallina officinalis. Experiments at room temperature showed that BPO readily catalyzes the conversion of 2,4-DBP and 2,4,6-TBP to HO-PBDEs in the presence of Br鈥?/sup> and H2O2. From analysis of the original forms and their corresponding methylated derivatives, the reaction products were tentatively identified as 2鈥?HO-BDE-121 and 4鈥?HO-BDE-121. The formation of HO-PBDEs was likely resulted from the coupling of bromophenoxy radicals generated by the oxidation of BPs via BPO-mediated processes. The presence of Br鈥?/sup> in the reaction favored the conversion. The production of HO-PBDEs was found to be pH-dependent, and a higher yield was obtained at pH 6.5. In view of the abundance of BPs and C. officinalis in the marine environment, bioconversion of BPs mediated by BPO may be a potential route for the natural production of HO-PBDEs.