Pd-Catalyzed Multidehydrogenative Cross-Coupling between (Hetero)Arenes and Nitroethane to Construct 尾-Aryl Nitroethylenes

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• 作者：Min Zhang ; Peng Hu ; Jun Zhou ; Ge Wu ; Shijun Huang ; Weiping Su
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：15
• 期：7
• 页码：1718-1721
• 全文大小：240K
• 年卷期：v.15,no.7(April 5, 2013)
• ISSN：1523-7052

文摘

The Pd-catalyzed multidehydrogenative cross-coupling reactions of arenes with nitroethane are described. The established methods afford 尾-aryl nitroethylenes that are an important class of synthetic intermediates and biologically active compounds in an atom- and step-economical fashion. The reactions were applicable to substituted benzenes and a variety of heterocycles such as benzothiophenes, benzofurans, and indoles. Mechanistic experiments indicated that 尾-nitroethylbenzene might be the intermediate in this transformation.