Privilege Ynone Synthesis via Palladium-Catalyzed Alkynylation of 鈥淪uper-Active Esters鈥?/a>Bo Yu, Huaming Sun, Zunyuan Xie, Guofang Zhang, Li-Wen Xu, Weiqiang Zhang, a

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• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 2, 2015
• 年：2015
• 卷：17
• 期：13
• 全文大小：309K
• ISSN：1523-7052

文摘

A neat palladium-catalyzed alkynylation reaction was developed with 鈥渟uper-active ester鈥?as the carbonyl electrophile, which provides a clean and efficient synthetic protocol for a broad array of ynone compounds under CO-, Cu-, ligand-, and base-free conditions. The superior activity of triazine ester was rationalized by the strong electron-withdrawing ability and the unique affinity of triazine on palladium. A mechanistic experiment clearly demonstrated that the N鈥揚d coordination of triazine plays a crucial role for the highly efficient C鈥揙 activation.