Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and 伪-Glucosidase

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• 作者：Kai Wang ; Li Bao ; Weiping Xiong ; Ke Ma ; Junjie Han ; Wenzhao Wang ; Wenbing Yin ; Hongwei Liu
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：August 28, 2015
• 年：2015
• 卷：78
• 期：8
• 页码：1977-1989
• 全文大小：587K
• ISSN：1520-6025

文摘

Sixteen new lanostane triterpenes, ganoleucoins A鈥揚 (1鈥?b>16), together with 10 known tripterpenes (17鈥?b>26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1鈥?b>26 on HMG-CoA reductase and 伪-glucosidase were tested in vitro. Compounds 1, 3, 6, 10鈥?b>14, 17, 18, 23, 25, and 26 showed much stronger inhibitory activity against HMG-CoA reductase than the positive control atorvastatin. Compounds 13, 14, and 16 presented potent inhibitory activity against 伪-glucosidase from yeast with IC₅₀ values of 13.6, 2.5, and 5.9 渭M, respectively. In addition, the cytotoxicity of 1鈥?b>26 was evaluated against the K562 and PC-3 cell lines by the MTT assay. Compounds 1, 2, 6, 7, 10, 12, 16, 18, and 25 exhibited cytotoxicity against K562 cells with IC₅₀ values in the range 10鈥?0 渭M. Paclitaxel was used as the positive control with an IC₅₀ value of 0.9 渭M. This is the first report of secondary metabolites from this medicinal mushroom.