Efficient Chiral Monophosphorus Ligands for Asymmetric Suzuki鈥揗iyaura Coupling Reactions
详细信息 查看全文
- 作者：Wenjun Tang ; Nitinchandra D. Patel ; Guangqing Xu ; Xiaobing Xu ; Jolaine Savoie ; Shengli Ma ; Ming-Hong Hao ; Santosh Keshipeddy ; Andrew G. Capacci ; Xudong Wei ; Yongda Zhang ; Joe J. Gao ; Wenjie Li ; Sonia Rodriguez ; Bruce Z. Lu ; Nathan K. Yee ; Chris H. Senanayake
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：May 4, 2012
- 年：2012
- 卷：14
- 期：9
- 页码：2258-2261
- 全文大小：260K
- 年卷期：v.14,no.9(May 4, 2012)
- ISSN：1523-7052
文摘
A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki鈥揗iyaura coupling reactions, enabling the construction of an array of chiral biaryl products in high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety in these chiral biaryl products allows facile derivatization for further synthetic applications. A computational study has revealed that a 蟺鈥撓€ interaction between the two coupling partners can enhance the enantioselectivity of the coupling reaction.