Enantioselective Synthesis of Optically Pure 尾-Amino Ketones and 纬-Aryl Amines by Rh-Catalyzed Asymmetric Hydrogenation

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• 作者：Huiling Geng ; Kexuan Huang ; Tian Sun ; Wei Li ; Xiaowei Zhang ; Le Zhou ; Wenjun Wu ; Xumu Zhang
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：January 7, 2011
• 年：2011
• 卷：76
• 期：1
• 页码：332-334
• 全文大小：758K
• 年卷期：v.76,no.1(January 7, 2011)
• ISSN：1520-6904

文摘

A series of optically pure 尾-amino ketones have been synthesized in high enantioselectivities (ee > 99%) by Rh-DuanPhos-catalyzed asymmetric hydrogenation of readily prepared 尾-keto enamides. Further reduction of these 尾-amino ketones with hydrogen and Pd/C leads to the formation of a variety of protected enantiomerically pure 纬-aryl amines (ee > 99%), which are key building blocks in many bioactive molecules.