Highly Regioselective Isomerization鈥揌ydroaminomethylation of Internal Olefins Catalyzed by Rh Complex with Tetrabi-Type Phosphorus Ligands

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• 作者：Guodu Liu ; Kexuan Huang ; Bonan Cao ; Mingxin Chang ; Shengkun Li ; Shichao Yu ; Le Zhou ; Wenjun Wu ; Xumu Zhang
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：14
• 期：1
• 页码：102-105
• 全文大小：721K
• 年卷期：v.14,no.1(January 6, 2012)
• ISSN：1523-7052

文摘

A highly regioselective isomerization鈥揾ydroaminomethylation of internal olefins has been developed. A 95.3% amine selectivity and 36.2 n/i ratio were obtained for 2-octene with a Tetrabi ligand and Rh(acac)(CO)₂, and a TON of linear amine was achieved of 6837 with a 39.1 n/i ratio of amine. The m-CF₃-Ph substituted ligand was the best of the applied Tetrabi-type phosphorus ligands for different internal olefins, as up to a 99.2% amine selectivity and 95.6 n/i ratio were obtained for 2-pentene.