Self-Illuminating 64Cu-Doped CdSe/ZnS Nanocrystals for in Vivo Tumor Imaging

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• 作者：Xiaolian Sun ; Xinglu Huang ; Jinxia Guo ; Wenlei Zhu ; Yong Ding ; Gang Niu ; Andrew Wang ; Dale O. Kiesewetter ; Zhong Lin Wang ; Shouheng Sun ; Xiaoyuan Chen
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：February 5, 2014
• 年：2014
• 卷：136
• 期：5
• 页码：1706-1709
• 全文大小：266K
• ISSN：1520-5126

文摘

Construction of self-illuminating semiconducting nanocrystals, also called quantum dots (QDs), has attracted much attention recently due to their potential as highly sensitive optical probes for biological imaging applications. Here we prepared a self-illuminating QD system by doping positron-emitting radionuclide ⁶⁴Cu into CdSe/ZnS core/shell QDs via a cation-exchange reaction. The ⁶⁴Cu-doped CdSe/ZnS QDs exhibit efficient Cerenkov resonance energy transfer (CRET). The signal of ⁶⁴Cu can accurately reflect the biodistribution of the QDs during circulation with no dissociation of ⁶⁴Cu from the nanoparticles. We also explored this system for in vivo tumor imaging. This nanoprobe showed high tumor-targeting ability in a U87MG glioblastoma xenograft model (12.7% ID/g at 17 h time point) and feasibility for in vivo luminescence imaging of tumor in the absence of excitation light. The availability of these self-illuminating integrated QDs provides an accurate and convenient tool for in vivo tumor imaging and detection.