Penicyclones A鈥揈, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2

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• 作者：Wenqiang Guo ; Zhenzhen Zhang ; Tianjiao Zhu ; Qianqun Gu ; Dehai Li
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2699-2703
• 全文大小：333K
• ISSN：1520-6025

文摘

Five new ambuic acid analogues, penicyclones A鈥揈 (1鈥?b>5), were isolated from the extract of the deep-sea-derived fungus Penicillium sp. F23-2. The structures including the absolute configurations were established by interpretation of NMR and MS data, as well as the application of ECD, X-ray crystallography, and a chemical conversion, as well as the TDDFT-ECD calculations. Penicyclones A鈥揈 (1鈥?b>5) exhibited antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus with MIC values ranging from 0.3 to 1.0 渭g/mL.