Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

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• 作者：Min Yin ; Yijun Yan ; Jeremy R. Lohman ; Sheng-Xiong Huang ; Ming Ma ; Guang-Rong Zhao ; Li-Hua Xu ; Wensheng Xiang ; Ben Shen
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：16
• 期：11
• 页码：3072-3075
• 全文大小：274K
• 年卷期：v.16,no.11(June 6, 2014)
• ISSN：1523-7052

文摘

Cycloheximide (1) and actiphenol (2) have been isolated from numerous Streptomyces species. Cloning, sequencing, and characterization of a gene cluster from Streptomyces sp. YIM65141 now establish that 1 and 2 production is governed by single biosynthetic machinery. Biosynthesis of 1 features an acyltransferase-less type I polyketide synthase to construct its carbon backbone but may proceed via 2 as a key intermediate, invoking a provocative reduction of a phenol to a cyclohexanone moiety in natural product biosynthesis.