Use of the Interparticle i-Motif for the Controlled Assembly of Gold Nanoparticles

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• 作者：Wenxing Wang ; Huajie Liu ; Dongsheng Liu ; Yun Xu ; Yang Yang ; Dejian Zhou
• 刊名：Langmuir
• 出版年：2007
• 出版时间：November 20, 2007
• 年：2007
• 卷：23
• 期：24
• 页码：11956 - 11959
• 全文大小：147K
• 年卷期：v.23,no.24(November 20, 2007)
• ISSN：1520-5827

文摘

In this letter, we present a new design that uses single-stranded (ss) DNAs containing two stretches of cytosine(C)-rich domains for the controlled assembly of gold nanoparticles (Au NPs). We show that this assembly is drivenby the formation of interparticle i-motif (four-stranded C-quadruplex) structures formed between the C-rich domainsof the ssDNAs on neighboring Au NPs. The assembly happens only at slightly acidic pH conditions (pHs below thepK_a of the i-motif). The assembly is reversible and can be switched by changing the solution pH. The assembly anddisassembly process is accompanied by distinct color changes that are clearly visible to the naked eye. This developmentmay have applications in the controlled assembly of reversible pH-sensitive nanostructures and/or devices.