Synthesis of 4-Cyano Pyrroles via Mild Knorr Reactions with -Ketonitriles
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- 作者：Nicholas A. Magnus ; Michael A. Staszak ; Uko E. Udodong ; James P. Wepsiec
- 刊名：Organic Process Research & Development
- 出版年：2006
- 出版时间：September 2006
- 年：2006
- 卷：10
- 期：5
- 页码：899 - 904
- 全文大小：117K
- 年卷期：v.10,no.5(September 2006)
- ISSN：1520-586X
文摘
Mild methods for conducting Knorr chemistry with 
-ketonitriles were developed. This enabled the preparation of 4-cyano-penta-substituted pyrroles and gave access to 
-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptorpotentiators for biological evaluation. In addition, a series ofalkyl and aryl -ketonitriles were employed in Knorr cyclizations to probe steric tolerance and the possibility of directintroduction of aromatic moieties via Knorr chemistry.
-ketonitriles were developed. This enabled the preparation of 4-cyano-penta-substituted pyrroles and gave access to -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptorpotentiators for biological evaluation. In addition, a series ofalkyl and aryl -ketonitriles were employed in Knorr cyclizations to probe steric tolerance and the possibility of directintroduction of aromatic moieties via Knorr chemistry.