Mesoscale Flow Chemistry: A Plug-Flow Approach to Reaction Optimisation

详细信息    查看全文

• 作者：Rob C. Wheeler ; Otman Benali ; Martyn Deal ; Elizabeth Farrant ; Simon J. F. MacDonald ; Brian H. Warrington
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：July 2007
• 年：2007
• 卷：11
• 期：4
• 页码：704 - 710
• 全文大小：625K
• 年卷期：v.11,no.4(July 2007)
• ISSN：1520-586X

文摘

In recent years, chemistry in flowing systems has become moreprominent as a method of carrying out chemical transformations, ranging in scale from analytical-scale (microchemistry)through to kilogram-scale synthesis (macrochemistry). Theadvantages are readily apparent-increased control of conditions leading to greater reproducibility, scaleability, and increased safety/reduced loss-although its acceptance as a viablesynthesis technique has been limited due to its drawbacks,primarily precipitation, liquid handling, and diffusion of thereaction within the reactor. Here, we present details of a systemwhich bridges the gap between micro- and macroreactors andhas enabled fast reaction optimisation (using small amounts ofreagents) and subsequent multigram scale-up using a commercial reactor.