Escherichia coli Glucuronylsynthase: An Engineered Enzyme for the Synthesis of -Glucuronides

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• 作者：Shane M. Wilkinson ; Chu W. Liew ; Joel P. Mackay ; Hamzah M. Salleh ; Stephen G. Withers ; Malcolm D. McLeod
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：April 17, 2008
• 年：2008
• 卷：10
• 期：8
• 页码：1585 - 1588
• 全文大小：75K
• 年卷期：v.10,no.8(April 17, 2008)
• ISSN：1523-7052

文摘

The glycosynthase derived from E. coli mages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols withmoderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of mages/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-glucuronides undermild conditions.