Multifunctional Polymeric Nanoparticles from Diverse Bioactive Agents

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• 作者：Paul A. Bertin ; Julianne M. Gibbs ; Clifton Kwang-Fu Shen ; C. Shad Thaxton ; William A. Russin ; Chad A. Mirkin ; and SonBinh T. Nguyen
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：April 5, 2006
• 年：2006
• 卷：128
• 期：13
• 页码：4168 - 4169
• 全文大小：176K
• 年卷期：v.128,no.13(April 5, 2006)
• ISSN：1520-5126

文摘

We present a rational approach for assembling diverse bioactive agents, such as DNA, proteins, and drug molecules, into core-shell multifunctional polymeric nanoparticles (PNPs) that can be internalized in human breast cancer cells. Using ring-opening metathesis polymerization (ROMP), block copolymers containing small-molecule drug segments (>50% w/w) and tosylated hexaethylene glycol segments were prepared and assembled into PNPs that allowed for the surface conjugation of single-stranded DNA sequences and/or tumor-targeting antibodies. The resulting antibody-functionalized particles were readily uptaken by breast cancer cells that overexpressed the corresponding antigens.