The Ansacarbamitocins: Polar Ansamitocin Derivatives
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- 作者：Carl E. Snipes ; Dennis O. Duebelbeis ; Monica Olson ; Donald R. Hahn ; William H. Dent III ; Jeffrey R. Gilbert ; Todd L. Werk ; George E. Davis ; Rebecca Lee-Lu ; Paul R. Graupner
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：October 2007
- 年：2007
- 卷：70
- 期：10
- 页码：1578 - 1581
- 全文大小：98K
- 年卷期：v.70,no.10(October 2007)
- ISSN：1520-6025
文摘
The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A–F (1–6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 (7, 8) additionally lack the epoxide group on C-4 and C-5.