Iodide as an Activating Agent for Acid Chlorides in Acylation Reactions

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• 作者：Russell J. Wakeham ; James E. Taylor ; Steven D. Bull ; James A. Morris ; Jonathan M. J. Williams
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：February 1, 2013
• 年：2013
• 卷：15
• 期：3
• 页码：702-705
• 全文大小：226K
• 年卷期：v.15,no.3(February 1, 2013)
• ISSN：1523-7052

文摘

Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel鈥揅rafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate.