Cladoniamides A−G, Tryptophan-Derived Alkaloids Produced in Culture by Streptomyces uncialis
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- 作者：David E. Williams ; Julian Davies ; Brian O. Patrick ; Helen Bottriell ; Tamsin Tarling ; Michel Roberge ; Raymond J. Andersen
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：August 21, 2008
- 年：2008
- 卷：10
- 期：16
- 页码：3501-3504
- 全文大小：167K
- 年卷期：v.10,no.16(August 21, 2008)
- ISSN：1523-7052
文摘
Cladoniamides A−G (3−9) have been isolated from cultures of Streptomyces uncialis, and their structures have been elucidated by a combination of spectroscopic analysis and an X-ray diffraction analysis of cladoniamide A (3). The cladoniamides have unprecedented rearranged and degraded alkaloid skeletons with putative biogenetic origins from indolocarbazole precursors. Cladoniamide G (9) is cytotoxic to MCF-7 cells in vitro at 10 μg/mL.