Intramolecular Hydrogen Transfer Reactions of Thiyl Radicals from Glutathione: Formation of Carbon-Centered Radical at Glu, Cys, and Gly

详细信息    查看全文

• 作者：Olivier Mozziconacci ; Todd D. Williams ; Christian Sch枚neich
• 刊名：Chemical Research in Toxicology
• 出版年：2012
• 出版时间：September 17, 2012
• 年：2012
• 卷：25
• 期：9
• 页码：1842-1861
• 全文大小：1140K
• 年卷期：v.25,no.9(September 17, 2012)
• ISSN：1520-5010

文摘

Glutathione thiyl radicals (GS^{鈥?/sup>) were generated in H₂O and D₂O by either exposure of GSH to AAPH, photoirradiation of GSH in the presence of acetone, or photoirradiation of GSSG. Detailed interpretation of the fragmentation pathways of deuterated GSH and GSH derivatives during mass spectrometry analysis allowed us to demonstrate that reversible intramolecular H-atom transfer reactions between GS鈥?/sup> and C鈥揌 bonds at Cys[伪C], Cys[尾C], and Gly[伪C] are possible.}