Expedient Synthesis of Substituted (Diphenylphosphinoylmethyl)benzenes

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• 作者：Sean P. Bew ; Rebecca A. Brimage ; David L. Hughes ; Laurent Legentil ; Sunil V. Sharma ; Martin A. Wilson
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：March 30, 2007
• 年：2007
• 卷：72
• 期：7
• 页码：2655 - 2658
• 全文大小：88K
• 年卷期：v.72,no.7(March 30, 2007)
• ISSN：1520-6904

文摘

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An efficient protocol for the synthesis of structurally diverse(diphenylphosphinoylmethyl)benzenes is described. Thereaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97%reduction in the reaction times and substantially higher yieldsof products result, up to a 60% increase, if the reactions areperformed under microwave irradiation. The first examplesof transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported.