DNA Alkylation Properties of Yatakemycin
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- 作者：Jay P. Parrish ; David B. Kastrinsky ; Scott E. Wolkenberg ; Yasuhiro Igarashi ; and Dale L. Boger
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：September 10, 2003
- 年：2003
- 卷：125
- 期：36
- 页码：10971 - 10976
- 全文大小：420K
- 年卷期：v.125,no.36(September 10, 2003)
- ISSN：1520-5126
文摘
Yatakemycin represents the newest and now most potent member of a class of naturally occurringantitumor compounds that includes CC-1065 and the duocarmycins, which derive their biological propertiesfrom a characteristic DNA alkylation reaction. Herein, the first description of the yatakemycin DNA alkylationproperties is detailed, constituting the first such study of a naturally occurring "sandwiched" member of thisclass. Thus, the event, sequence selectivity, relative rate and efficiency, and reversibility of the DNA alkylationreaction of yatakemycin are described.