Malaria-Infected Mice Are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine
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- 作者：Rachel D. Slack ; Bryan T. Mott ; Lauren E. Woodard ; Abhai Tripathi ; David Sullivan ; Elizabeth Nenortas ; Sonya C. T. Girdwood ; Theresa A. Shapiro ; Gary H. Posner
- 刊名：Journal of Medicinal Chemistry
- 出版年：2012
- 出版时间：January 12, 2012
- 年：2012
- 卷：55
- 期：1
- 页码：291-296
- 全文大小：281K
- 年卷期：v.55,no.1(January 12, 2012)
- ISSN：1520-4804
文摘
Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSanilide 12d was completely curative: on day 30 after infection, all mice in this group had no detectable parasitemia, gained as much weight as the uninfected control mice, and behaved normally.