Intercepting Bacterial Indole Signaling with Flustramine Derivatives

详细信息    查看全文

• 作者：Cynthia A. Bunders ; Marine J. Minvielle ; Roberta J. Worthington ; Minoshka Ortiz ; John Cavanagh ; Christian Melander
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：December 21, 2011
• 年：2011
• 卷：133
• 期：50
• 页码：20160-20163
• 全文大小：766K
• 年卷期：v.133,no.50(December 21, 2011)
• ISSN：1520-5126

文摘

Indole signaling is one of the putative universal signaling networks in bacteria. We have investigated the use of desformylflustrabromine (dFBr) derivatives for the inhibition of biofilm formation through modulation of the indole-signaling network in Escherichia coli and Staphylococcus aureus. We have found dFBr derivatives that are 10鈥?000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.