Overcoming Resistance to 尾-Lactam Antibiotics

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• 作者：Roberta J. Worthington ; Christian Melander
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：May 3, 2013
• 年：2013
• 卷：78
• 期：9
• 页码：4207-4213
• 全文大小：326K
• 年卷期：v.78,no.9(May 3, 2013)
• ISSN：1520-6904

文摘

尾-Lactam antibiotics are one of the most important antibiotic classes but are plagued by problems of resistance, and the development of new 尾-lactam antibiotics through side-chain modification of existing 尾-lactam classes is not keeping pace with resistance development. In this JOCSynopsis, we summarize small molecule strategies to overcome resistance to 尾-lactam antibiotics. These approaches include the development of 尾-lactamase inhibitors and compounds that interfere with the ability of the bacteria to sense an antibiotic threat and activate their resistance mechanisms.