Synthesis, Structural Characterization, and Antiinflammatory Activity of Triethylphosphinegold(I) Sulfanylpropenoates of the Type [(AuPEt3)2xspa] [H2xspa = 3-(Aryl)-2-

详细信息    查看全文

• 作者：Elena Barreiro ; Jose&#x301 ; S. Casas ; Mari&#x301 ; a D. Couce ; A&#x301 ; ngeles Gato ; Agusti&#x301 ; n Sa&#x301 ; nchez ; Jose&#x301 ; Sordo ; Jose&#x301 ; M. Varela ; Ezequiel M. Va&#x301 ; zquez Lo&#x301 ; pez
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：July 21, 2008
• 年：2008
• 卷：47
• 期：14
• 页码：6262 - 6272
• 全文大小：1689K
• 年卷期：v.47,no.14(July 21, 2008)
• ISSN：1520-510X

文摘

Gold complexes of the type [(AuPEt₃)₂xspa] were prepared by reacting AuPEt₃Cl in basic media with the 3-(aryl)-2-sulfanylpropenoic acids H₂xspa [x = p, Clp, -o-mp, -p-mp, -o-hp, -p-hp, diBr-o-hp, f, t, -o-py; p = 3-phenyl, Clp = 3-(2-chlorophenyl)-, -o-mp = 3-(2-methoxyphenyl)-, -p-mp = 3-(4-methoxyphenyl)-, -o-hp = 3-(2-hydroxyphenyl)-, -p-hp = 3-(4-hydroxyphenyl)-, diBr-o-hp = 3-(3,5- dibromo-2-hydroxyphenyl)-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, -o-py = 3-(2-pyridyl); spa = 2-sulfanylpropenoato], and 2-cyclopentylidene-2-sulfanylacetic acid (H₂cpa). The complexes were characterized by spectroscopic methods (IR, ¹H, ¹³C and ³¹P NMR) and mass spectrometry, and the complexes [(AuPEt₃)₂pspa]·3H₂O, [(AuPEt₃)₂-p-hpspa]·3H₂O, [(AuPEt₃)₂tspa)]·3H₂O, and [(AuPEt₃)₂-o-hpspa] by X-ray diffractometry. The crystals of the first three complexes contain (H₂O)₆ clusters hydrogen bonded to [(AuPEt₃)₂xspa]₂ dimer units, whereas in the -o-hpspa derivative the hydrogen bonds are between the monomer [(AuPEt₃)₂-o-hpspa] units. The antiinflammatory activity of the complexes against plantar edema induced by carrageenan in rats is generally significant, with the values for the o-hpspa and tspa derivatives being particularly high.